Precision Medicine – A Huge Challenge for Hospital Decision Makers

The healthcare sector has gained its entry into the new era of genomics and precision medicine. There are numerous health IT vendors, who offer to help healthcare providers by providing the right data with the objective of utmost patient care.

 A report from KLAS Precision Medicine Vendor Validations 2018 showed the present condition of many hospitals. "They find it confusing to determine which of the hundreds of vendors in the market will be most helpful."

Many hospitals consider precision medicine as the domain of academic medical centers where there are resources to do the needful. Henceforth, community hospitals were also planning to integrate personalized precision medicine.

Nephi Walton, MD, assistant professor of genomic medicine at Geisinger said, “Pretty soon, precision medicine may be considered the standard of care.”

Around 13 precision medicine based analytics firms offered responses in detail about their efficiencies across the domains. 2bPrecise, Gene42, Fabric Genomics, IBM Watson Health, NantHealth, LifeOmic, Navican, Philips, N-of-One, PierianDx, Tempus, Sunquest Information Systems and Translational Software.

A successful precision medicine program involves many tools and specialized skills such as clinical decision support technology, biomedical research analytics, laboratory information management systems, provider-facing clinical analytics, care planning capabilities for evidence-based treatments, patient population genetic data repositories, platforms to manage clinical trials and business intelligence tools for the enhanced genomics-based care. Many technologies are specifically targeted for highly-specialized population health managers and clinical end-users such as physicians, pathologists and oncologists.

Since all the vendors offer numerous tools, it is a great challenge for hospital decision-makers to differentiate qualitative ones from the hype.

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Create Personalized Bone Grafts with SATE

A team of scientists from the New York Stem Cell Foundation (NYSCF) Research Institute has developed a new bone engineering technique named Segmental Additive Tissue Engineering (SATE). With this technique, segments of bone engineered from stem cells fuse together to form large-scale, personalized grafts.

Susan Solomon, the CEO of NYSCF said, “We are hopeful that SATE will one day be able to improve the lives of the millions of people suffering from bone injury due to trauma, cancer, osteoporosis, osteonecrosis, and other devastating conditions. Our goal is to help these patients return to normal life, and by leveraging the power of regenerative medicine, SATE brings us one step closer to reaching that goal.”

Dr Giuseppe de Peppo, the leader of this study said, “Bone defects obtained in disease or injury are a growing issue, and having effective treatment options in place for personalized relief, no matter the severity of a patient’s condition, is of critical importance.”

Dr Martina Sladkova, the first author and NYSCF researcher said, “As the size of the defect that needs to be replaced gets larger, it becomes harder to reproducibly create a graft that can move from the lab to the clinic. We wanted to see if we could instead engineer smaller segments of bone individually and then combine them to create a graft that overcomes the current limitations in the size and shape of a bone that can be grown in the lab.”

The research team claimed that SATE is versatile, standardized, as well as easily implemented. The quality of life of both children and adults who are suffering from segmental bone defects could be improved by enabling bone graft engineering.

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